Description

Cholylglycylhistamine is a synthetic bile acid derivative and a conjugate of cholic acid with the dipeptide glycylhistamine. This compound is a valuable biochemical tool and a key intermediate in the development of targeted diagnostic and therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in hepatobiliary research, receptor studies, and the synthesis of novel conjugates for drug delivery systems.

Application

• Biochemical Research: Used as a reference standard and intermediate in studies of bile acid transport and metabolism.
• Pharmaceutical Development: Serves as a key building block for synthesizing targeted prodrugs and diagnostic agents for liver-specific delivery.
• Receptor Ligand Studies: Employed in the investigation of bile acid receptors (e.g., TGR5, FXR) and related signaling pathways.
• Conjugate Synthesis: Acts as a versatile intermediate for creating peptide-bile acid conjugates to enhance cellular uptake.
• Diagnostic Agent Precursor: Utilized in the development of contrast agents or radiolabeled compounds for hepatobiliary imaging.

Basic Information

Product Name	Cholylglycylhistamine
CAS No.	61601-56-7
Molecular Formula	C32H53N5O6
Molecular Weight	603.80 g/mol
Synonyms	Cholyl-Gly-His; Glycocholyglycine Histamine; N-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycylhistamine; Taurocholic acid glycylhistamine analog; Bile acid-peptide conjugate; Cholic acid-glycylhistamine amide
EINECS	Contact for details

Quality Control

Our Cholylglycylhistamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.