Description

Boc-Hyp-Ol CAS NO 61478-26-0 is a protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) derivative of hydroxyprolinol. This compound serves as a crucial chiral building block and intermediate in advanced organic synthesis, particularly in the pharmaceutical and peptide research sectors. Its primary value lies in providing a protected amine group, enabling selective reactions during the construction of complex molecules like peptide-based drugs and bioactive compounds. This makes it essential for R&D chemists and process development scientists working on novel therapeutics, diagnostics, and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of peptide-based active pharmaceutical ingredients (APIs) and prodrugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the hydroxyproline moiety with orthogonal protection.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design and synthesis of inhibitors targeting specific enzymes.
• Chemical Biology & Probe Synthesis: Employed in the creation of labeled compounds and molecular probes for studying biological mechanisms.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material for the enantioselective construction of complex natural products and analogs.
• Glycopeptide & Conjugate Chemistry: Acts as a linker or modified amino acid unit in the synthesis of glycopeptides and other bioconjugates.

Basic Information

Product Name	Boc-Hyp-Ol
CAS No.	61478-26-0
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxaldehyde; N-Boc-trans-4-Hydroxy-L-prolinol; Boc-4(R)-Hydroxy-L-prolinol; tert-Butyl (4R)-4-hydroxy-L-prolinate derivative; N-(tert-Butoxycarbonyl)-trans-4-hydroxy-L-prolinol; Boc-trans-4-hydroxy-L-prolinol; (4R)-1-[(2-Methyl-2-propanyl)oxycarbonyl]-4-hydroxy-2-pyrrolidinecarboxaldehyde
EINECS	Contact for details

Quality Control

Our Boc-Hyp-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.