Description

L-Proline, 4-Hydroxy-, Ethyl Ester, (4R)- (9Ci) is a chiral, non-proteinogenic amino acid derivative that serves as a critical building block in advanced organic synthesis. This high-purity intermediate is valued for its role in constructing complex molecular architectures, particularly in the synthesis of pharmaceuticals and bioactive compounds. It is essential for research and production in pharmaceutical development, agrochemicals, and fine chemical manufacturing where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce the 4-hydroxyproline moiety, which can influence peptide conformation and stability.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides and plant growth regulators with specific stereochemical requirements.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, and fragrances that require high enantiomeric purity.
• Cosmetic Ingredient Synthesis: A potential intermediate for synthesizing peptides used in anti-aging and skin-care formulations.

Basic Information

Product Name	L-Proline, 4-Hydroxy-, Ethyl Ester, (4R)- (9Ci)
CAS No.	61478-25-9
Molecular Formula	C7H13NO4
Molecular Weight	175.18 g/mol
Synonyms	(4R)-4-Hydroxy-L-proline ethyl ester; Ethyl (4R)-4-hydroxypyrrolidine-2-carboxylate; L-4-Hydroxyproline ethyl ester; Ethyl L-4-hydroxyprolinate; 4-Hydroxy-L-proline ethyl ester; trans-4-Hydroxy-L-proline ethyl ester; (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid ethyl ester; Hyp-OEt
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Hydroxy-, Ethyl Ester, (4R)- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The compound is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.