Description

Gln4 Neurotensin CAS NO 61445-54-3 is a synthetic peptide analog of the endogenous neuropeptide neurotensin, specifically modified at the fourth position with a glutamine residue. This compound is of significant interest for its role in modulating neurotransmitter systems and its potential applications in neuroscience research and drug discovery. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in studying neurological disorders, receptor-ligand interactions, and peptide-based therapeutics.

Application

• Neuroscience Research: Used as a specific ligand to study the binding, function, and distribution of neurotensin receptors (NTS1 and NTS2) in the central nervous system.
• Pharmacological Studies: Employed in in vitro and in vivo assays to investigate the physiological effects of neurotensin, such as hypothermia, analgesia, and modulation of dopamine pathways.
• Drug Discovery & Development: Serves as a reference standard or a lead compound in the development of novel neurotensin receptor agonists or antagonists for treating conditions like schizophrenia, pain, and Parkinson's disease.
• Biochemical Assays: Utilized in receptor binding assays, cell signaling studies, and second messenger system analysis to elucidate neurotensin-mediated pathways.
• Academic & Clinical Research: Supports fundamental research into the role of neuropeptides in behavior, addiction, and gastrointestinal motility.

Basic Information

Product Name	Gln4 Neurotensin
CAS No.	61445-54-3
Molecular Formula	C₈₀H₁₂₈N₂₄O₂₃
Molecular Weight	1834.0 g/mol
Synonyms	Gln4-Neurotensin; [Gln4]-Neurotensin; Neurotensin (4-Gln); pGlu-Leu-Tyr-Gln-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu; Neurotensin Fragment 1-13 (Gln4); NT (Gln4); Neurotensin Analog (Gln4); L-Glutamine Neurotensin Derivative
EINECS	Contact for details

Quality Control

Our Gln4 Neurotensin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.