Description

Tyr-D-Ala-Gly-Phe-Met CAS NO 61370-87-4 is a synthetic pentapeptide analog of the endogenous opioid peptide [Met]-enkephalin, featuring a D-alanine substitution at the second position. This modification enhances its metabolic stability, making it a critical tool for biochemical and pharmacological research into opioid receptor function and signal transduction pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, pain management research, and peptide drug discovery.

Application

• Biochemical Research: Used as a stable reference standard and ligand in studies of delta (δ) and mu (μ) opioid receptor binding, activation, and internalization.
• Pharmacological Assays: Serves as a key agonist in in vitro and cell-based assays to investigate analgesic pathways and the physiological effects of opioid peptides.
• Neuroscience Studies: Employed in research exploring the role of enkephalins in neurotransmission, behavior, and the modulation of pain perception.
• Drug Discovery & Development: Acts as a lead compound or a structural template for the design and synthesis of novel peptide-based therapeutics with improved stability and selectivity.
• Academic Research: A fundamental reagent for university laboratories conducting advanced studies in neurochemistry, molecular biology, and peptide science.

Basic Information

Product Name	Tyr-D-Ala-Gly-Phe-Met
CAS No.	61370-87-4
Molecular Formula	C30H40N6O7S
Molecular Weight	628.74 g/mol
Synonyms	[D-Ala2]-Met-Enkephalin; [D-Ala2]-Methionine Enkephalin; Tyr-D-Ala-Gly-Phe-Met-NH2 (Amidated form); DADME; Opioid peptide agonist; H-Tyr-D-Ala-Gly-Phe-Met-OH; YAGFM; Delta opioid receptor ligand
EINECS	Contact for details

Quality Control

Our Tyr-D-Ala-Gly-Phe-Met is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Conforms
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.