Description

Z-Val-Nhtbu (CAS NO 61274-17-7) is a high-purity, protected amino acid derivative widely used as a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex peptide chains and other bioactive molecules, ensuring high coupling efficiency and minimal racemization. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel therapeutic peptides and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled elongation of peptide sequences in automated synthesizers.
• Pharmaceutical Research: Serves as a crucial building block in the R&D of peptide-based drugs, hormone analogs, and enzyme inhibitors.
• Combinatorial Chemistry: Used in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins for diagnostic and therapeutic applications.
• Custom Peptide Manufacturing: Employed in the production of custom peptides for research, diagnostic, and preclinical development purposes.
• Chemical Biology: A valuable tool for studying protein-protein interactions and cellular signaling pathways using synthetic peptide probes.

Basic Information

Product Name	Z-Val-Nhtbu
CAS No.	61274-17-7
Molecular Formula	C17H24N2O5
Molecular Weight	336.39 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine; Fmoc-Val-OH; Fmoc-L-valine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-methylbutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]valine; Fmoc-Val; N-Fmoc-L-valine; N-α-Fmoc-L-valine
EINECS	Contact for details

Quality Control

Our Z-Val-Nhtbu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, to meet the stringent requirements of pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our rigorous specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	[α]20/D: -15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.