Description

4-Fluoro-2-Iodoaniline is a versatile halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring halogenated aromatic scaffolds.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and pesticides where the fluorine and iodine groups modulate biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An essential substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination, leveraging the reactive iodine site.
• Dye and Pigment Manufacturing: Intermediate for producing specialized azo dyes and colorants with specific light-fastness and hue properties.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process chemistry in exploring new synthetic routes and compound libraries.

Basic Information

Product Name	4-Fluoro-2-Iodoaniline
CAS No.	61272-76-2
Molecular Formula	C6H5FIN
Molecular Weight	237.01 g/mol
Synonyms	2-Iodo-4-fluoroaniline; 4-Fluoro-2-iodobenzenamine; 2-Iodo-4-fluorobenzenamine; 1-Amino-4-fluoro-2-iodobenzene; Benzenamine, 4-fluoro-2-iodo-; 4-Fluoro-o-iodoaniline; 4-Fluoro-2-iodo-phenylamine; 4-FA-2I
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Iodoaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.