Description

H-Tyr-D-Ala-Gly-Phe-Met-Nh2 is a synthetic pentapeptide amide, a sequence derived from endogenous opioid peptides. This compound is of significant interest in biochemical and pharmacological research due to its role in studying opioid receptor interactions and signal transduction pathways. It serves as a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical and life science sectors, particularly those focused on neurobiology, peptide therapeutics, and analgesic drug development.

Application

• Biochemical Research: Used as a reference standard and tool compound for studying the structure-activity relationships (SAR) of opioid peptides.
• Pharmacological Studies: Employed in in vitro and in vivo assays to investigate binding affinity, selectivity, and efficacy at mu-opioid and δ-opioid receptors.
• Pharmaceutical Development: Serves as a key intermediate in the synthesis of novel peptide-based analgesic candidates and therapeutic agents.
• Academic Research: A vital reagent for universities and research institutions exploring neuropeptide function, pain modulation, and central nervous system disorders.
• Quality Control: Utilized as a high-purity certified reference material (CRM) for analytical method development and validation in QC laboratories.

Basic Information

Product Name	H-Tyr-D-Ala-Gly-Phe-Met-Nh2
CAS No.	61090-95-7
Molecular Formula	C30H41N7O7S
Molecular Weight	643.76 g/mol
Synonyms	Tyr-D-Ala-Gly-Phe-Met-NH2; [D-Ala2]-Methionine Enkephalinamide; [D-Ala2]-Met-Enkephalinamide; H-Tyr-D-Ala-Gly-Phe-Met-NH2; DAMEA; Opioid peptide (D-Ala2, Met5)-enkephalinamide; YAGFM-NH2
EINECS	Contact for details

Quality Control

Our H-Tyr-D-Ala-Gly-Phe-Met-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting the results against stringent in-house specifications. Our commitment to quality and traceability supports critical research and cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.