Description

n-[(tert-Butoxy)Carbonyl]-3-Methyl-L-Histidine CAS NO 61070-22-2 is a protected derivative of the amino acid histidine, specifically engineered for advanced peptide synthesis and pharmaceutical research. This compound is critical for introducing the unique imidazole side chain of histidine into peptide chains while preventing unwanted side reactions during synthesis. It is an essential building block for researchers and manufacturers developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: A key protected amino acid for the solid-phase and solution-phase synthesis of complex peptide-based drugs and APIs.
• Peptide Research: Used in academic and industrial R&D for constructing novel peptides with histidine residues, crucial for catalysis and metal binding.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-drug conjugates used in targeted therapies and diagnostics.
• Enzyme Mimic Development: Employed in the design and synthesis of synthetic enzymes or catalysts that mimic the function of natural histidine-containing enzymes.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening to discover new bioactive compounds.

Basic Information

Product Name	n-[(tert-Butoxy)Carbonyl]-3-Methyl-L-Histidine
CAS No.	61070-22-2
Molecular Formula	C12H19N3O4
Molecular Weight	269.30 g/mol
Synonyms	Boc-3-Methyl-L-histidine; (2S)-2-[(tert-Butoxy)carbonylamino]-3-(3-methyl-1H-imidazol-4-yl)propanoic acid; N-Boc-3-methyl-L-histidine; Boc-MeHis-OH; tert-Butyloxycarbonyl-3-methyl-L-histidine; 3-Methyl-L-histidine N-Boc derivative; Nα-Boc-3-methyl-L-histidine; L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-
EINECS	Contact for details

Quality Control

Our n-[(tert-Butoxy)Carbonyl]-3-Methyl-L-Histidine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.