Description

(2R)-2-Amino-5-Phosphono-3-Pentenoic Acid CAS NO 60978-99-6 is a chiral, unsaturated amino acid derivative featuring a phosphonic acid group, making it a valuable non-hydrolyzable analog of glutamate. This compound matters as a potent and selective antagonist for specific glutamate receptor subtypes, serving as a critical research tool in neuropharmacology. It is primarily needed by pharmaceutical R&D teams, academic neuroscientists, and fine chemical manufacturers developing novel central nervous system (CNS) therapeutics and biochemical probes.

Application

• Neuroscience Research: As a selective NMDA (N-methyl-D-aspartate) receptor antagonist for studying excitatory neurotransmission, synaptic plasticity, and neurotoxicity.
• Pharmacological Probe Development: Used in high-throughput screening (HTS) and assay development to identify and characterize new modulators of glutamate pathways.
• Lead Compound Synthesis: Serves as a key chiral building block or pharmacophore in the medicinal chemistry synthesis of potential neuroprotective agents, anticonvulsants, or analgesics.
• Biochemical Studies: Investigation of enzyme-substrate interactions, particularly those involving glutamate decarboxylase or other enzymes in amino acid metabolism.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	(2R)-2-Amino-5-Phosphono-3-Pentenoic Acid
CAS No.	60978-99-6
Molecular Formula	C5H10NO5P
Molecular Weight	195.11 g/mol
Synonyms	(2R)-2-Amino-5-phosphonopent-3-enoic acid; (R)-AP5; (R)-2-Amino-5-phosphono-3-pentenoic acid; (R)-APV; D-AP5; (R)-2-Amino-5-phosphonopent-3-enoate; (2R)-2-Amino-5-phosphono-3-pentenoate; NMDA receptor antagonist (R)-AP5
EINECS	Contact for details

Quality Control

Every batch of (2R)-2-Amino-5-Phosphono-3-Pentenoic Acid is produced under strict quality management protocols. Our products undergo rigorous quality testing, including chiral purity verification and impurity profiling, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and specific tests is provided with each shipment to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.