Description

Hemoglobin Helsinki is a specific, naturally occurring variant of human hemoglobin characterized by a point mutation. This product is of significant interest for biochemical research and diagnostic development due to its unique structural and functional properties. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in hematology studies, hemoglobinopathy research, and the calibration of clinical analytical instruments.

Application

• Biochemical Research: Used as a standard or model compound in studies investigating oxygen-binding kinetics, protein stability, and the molecular pathology of hemoglobin disorders.
• Diagnostic Development: Serves as a critical reference material in the development and validation of diagnostic assays for detecting hemoglobin variants, such as high-performance liquid chromatography (HPLC) and capillary electrophoresis methods.
• Clinical Calibration: Employed for the calibration and quality control of laboratory analyzers in clinical hematology to ensure accurate identification and quantification of abnormal hemoglobins.
• Pharmaceutical Studies: Used in preclinical research focused on therapeutic strategies for sickle cell disease, thalassemia, and other hemoglobinopathies.
• Educational Purposes: Provides a tangible example for advanced teaching in biochemistry, molecular biology, and medical technology courses.

Basic Information

Product Name	Hemoglobin Helsinki
CAS No.	60937-63-5
Molecular Formula	C2952H4664N812O840S16Fe4
Molecular Weight	~64,500 Da (Tetramer)
Synonyms	Hb Helsinki; Hemoglobin variant Helsinki; α2β282 Lys→Asn; Hemoglobin α2 beta2 82(B6)Lys→Asn; Hemoglobin with high oxygen affinity Helsinki; HbH; Unii-9R5Y8Z5K5B; Human hemoglobin Helsinki
EINECS	Contact for details

Quality Control

Our Hemoglobin Helsinki is produced and handled under controlled conditions to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes rigorous analytical testing, including purity assessment by HPLC, spectral analysis, and functional oxygen-binding studies. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. This material is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot contents upon receipt to minimize degradation.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (Spectroscopy)	Characteristic Soret band (~414 nm)
Purity (HPLC)	≥ 95% (Hemoglobin Helsinki)
Methemoglobin Content	< 5%
Protein Content (Biuret)	≥ 90%
Solubility	Soluble in buffer (e.g., PBS, pH 7.4)
Oxygen Affinity (P50)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.