Description

2,3,5,6-Tetrafluoro-4-Methylbenzylchloride is a high-value fluorinated aromatic building block, essential for introducing the 2,3,5,6-tetrafluoro-4-methylbenzyl moiety into advanced molecular architectures. Its core value lies in enabling the synthesis of complex, performance-enhancing compounds where the unique electronic and steric properties of the perfluorinated methylbenzyl group are critical. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as in material science for developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Building block for advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal Materials: Used in the synthesis of fluorinated liquid crystals for high-performance displays (LCDs) due to its ability to modify dielectric anisotropy and viscosity.
• Specialty Polymer Monomer: Serves as a precursor for monomers that impart chemical resistance, low surface energy, and thermal stability to advanced polymeric materials.
• Organic Electronic Materials: Intermediate in the production of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-coupling Reactions: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Derivatization Agent: Acts as a derivatizing agent in analytical chemistry or for modifying surfaces and biomolecules.

Basic Information

Product Name	2,3,5,6-Tetrafluoro-4-Methylbenzylchloride
CAS No.	60903-84-6
Molecular Formula	C8H5ClF4
Molecular Weight	212.57 g/mol
Synonyms	4-(Chloromethyl)-2,3,5,6-tetrafluoro-1-methylbenzene; α-Chloro-2,3,5,6-tetrafluoro-4-methyltoluene; 2,3,5,6-Tetrafluoro-4-methylbenzyl Chloride; (2,3,5,6-Tetrafluoro-4-methylphenyl)methyl chloride; 4-Methyl-2,3,5,6-tetrafluorobenzyl chloride; Perfluoro-4-methylbenzyl Chloride; TFMBC
EINECS	Contact for details

Quality Control

Every batch of 2,3,5,6-Tetrafluoro-4-Methylbenzylchloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request. Our quality commitment supports compliance in cGMP and ISO-governed environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly sealed due to moisture sensitivity and potential reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.