Description

Anthopleurin-A is a potent polypeptide neurotoxin isolated from sea anemones, known for its specific action on voltage-gated sodium channels. This high-purity compound is critical for advanced research in neuropharmacology and cardiac electrophysiology. It serves as an invaluable tool for scientists and pharmaceutical developers in neuroscience, toxicology, and drug discovery sectors, particularly for studying ion channel function and developing novel therapeutic agents.

Application

• Neuroscience Research: As a specific modulator of voltage-gated sodium channels (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6) for studying neuronal excitability and signal transduction.
• Cardiac Electrophysiology Studies: Investigation of sodium channel function in heart muscle cells and related arrhythmia mechanisms.
• Pharmacological Tool Development: Used in the design and screening of new analgesic, anti-arrhythmic, or neuroprotective drug candidates.
• Toxicology & Venom Research: Reference standard for the analysis of marine toxins and studies on the mode of action of cnidarian venoms.
• Ion Channel Assays: Key reagent in high-throughput screening (HTS) platforms and patch-clamp experiments to characterize channel kinetics.
• Biochemical Standard: Used for calibrating analytical methods and as a purity standard in peptide research.

Basic Information

Product Name	Anthopleurin-A
CAS No.	60880-63-9
Molecular Formula	C~170~H~268~N~52~O~51~S~2
Molecular Weight	~4.9 kDa
Synonyms	AP-A; Anthopleurin A; Sea Anemone Toxin AP-A; Sodium Channel Neurotoxin AP-A; Polypeptide Toxin AP-A; ATX Ia; Anemonia sulcata Toxin II (As II) homolog
EINECS	Contact for details

Quality Control

Our Anthopleurin-A is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and identity. We adhere to rigorous quality testing protocols to guarantee batch-to-batch consistency and reliability for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (LD~50~)	Defined range (Contact for details)
Water Content (KF)	≤ 5.0%
Endotoxin Level (LAL)	< 1.0 EU/µg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.