Description

2,3,5,6-Tetramethylbenzenesulfonyl Chloride is a specialized sulfonyl chloride derivative, characterized by its sterically hindered tetramethyl-substituted benzene ring. This compound is a valuable high-purity synthetic intermediate and protecting group reagent, prized for its reactivity in introducing the sulfonyl moiety under controlled conditions. It is primarily utilized by pharmaceutical, agrochemical, and advanced material research laboratories for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of sulfonamide-based drugs and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and other crop protection agents requiring sulfonyl functional groups.
• Peptide Chemistry: Acts as a sulfonylation agent and protecting group for amino acids during peptide synthesis.
• Polymer & Material Science: Monomer or modifier for creating specialty polymers, dyes, and advanced functional materials.
• Chemical Research & Development: Essential reagent in organic synthesis for constructing complex molecular architectures in R&D settings.
• Cross-coupling Reactions: Serves as a precursor for catalysts or ligands used in palladium-catalyzed coupling reactions.

Basic Information

Product Name	2,3,5,6-Tetramethylbenzenesulfonyl Chloride
CAS No.	60706-63-0
Molecular Formula	C10H13ClO2S
Molecular Weight	232.73 g/mol
Synonyms	Durenolsulfonyl Chloride; 2,3,5,6-Tetramethylphenylsulfonyl Chloride; Durenesulfonyl Chloride; Tetramethylbenzenesulfonyl Chloride; 1,2,4,5-Tetramethylbenzenesulfonyl Chloride; Durenylsulfonyl Chloride; NSC 403697; Durene-2-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2,3,5,6-Tetramethylbenzenesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of research and industrial synthesis. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.