Description

2-(1,1,2,2,2-Pentafluoroethoxy)Phenol is a specialized fluorinated phenolic compound, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a pentafluoroethoxy substituent, provides enhanced lipophilicity and metabolic stability, making it a valuable intermediate for high-performance materials and active pharmaceutical ingredients. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty polymer industries seeking to incorporate fluorine for improved product properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and pesticides, where the fluorine moiety enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing mesogens and electron-transport materials, improving display performance and device efficiency.
• Polymer Modification: Acts as a monomer or additive for engineering plastics and high-performance polymers to impart flame retardancy, chemical resistance, and low surface energy.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce fluorinated aromatic ether functionalities into complex molecules.
• Surface Treatment & Coatings: Utilized in formulating specialty coatings that require oil, water, and stain repellency due to the low surface energy of the perfluoroalkyl ether group.

Basic Information

Item	Detail
Product Name	2-(1,1,2,2,2-Pentafluoroethoxy)Phenol
CAS No.	60702-00-3
Molecular Formula	C8H5F5O2
Molecular Weight	228.12 g/mol
Synonyms	2-(Pentafluoroethoxy)phenol; 1-Hydroxy-2-(pentafluoroethoxy)benzene; Phenol, 2-(1,1,2,2,2-pentafluoroethoxy)-; o-(Pentafluoroethoxy)phenol; 2-Hydroxyphenyl pentafluoroethyl ether; Pentafluoroethyl 2-hydroxyphenyl ether; CAS 60702-00-3
EINECS	Contact for details

Quality Control

Every batch of 2-(1,1,2,2,2-Pentafluoroethoxy)Phenol is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical-grade material meets rigorous in-house specifications, with testing typically including HPLC for assay and impurity profiling, NMR, and IR for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.