Description

Big Gastrin I Human CAS NO 60675-77-6 is a synthetic peptide hormone identical to the endogenous human gastrin-34, a key regulator of gastric acid secretion. This high-purity reference standard is critical for ensuring accuracy and reliability in advanced biomedical research and diagnostic assay development. It is primarily utilized by pharmaceutical R&D teams, clinical diagnostics manufacturers, and academic institutions focused on gastrointestinal physiology and related therapeutic areas.

Application

• Biomedical Research: Used as a precise reference standard in studies investigating gastric acid secretion, gastrointestinal hormone signaling, and related metabolic pathways.
• Diagnostic Assay Development: Serves as a critical calibrant and control in the manufacturing of immunoassay kits (e.g., ELISA, RIA) for measuring gastrin levels in clinical samples.
• Pharmaceutical R&D: Employed in drug discovery programs targeting gastrin receptors (CCK2R) for potential therapies in conditions like peptic ulcers or Zollinger-Ellison syndrome.
• Quality Control & Validation: Essential for the qualification and routine QC of analytical methods (HPLC, MS) in laboratories requiring high-fidelity peptide standards.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to stimulate gastrin receptor activity and study downstream cellular responses.

Basic Information

Product Name	Big Gastrin I Human
CAS No.	60675-77-6
Molecular Formula	C₁₇₀H₂₄₆N₄₄O₅₅S
Molecular Weight	3839.3 g/mol
Synonyms	Human Gastrin I (34); Gastrin-34; HG-34; Big Gastrin; G34; pGlu-Leu-Gly-Pro-Gln-Gly-Pro-Pro-His-Leu-Val-Ala-Asp-Pro-Ser-Lys-Lys-Gln-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH₂; Cholecystokinin-2 (CCK2) Receptor Ligand; Gastrointestinal Hormone
EINECS	Contact for details

Quality Control

Our Big Gastrin I Human is manufactured under strict quality systems to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research and diagnostic applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from multiple orthogonal analytical techniques, including HPLC and mass spectrometry. We are committed to providing materials that meet the rigorous demands of the life sciences industry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.