Description

7-Chloro-1,3Dihydro-5-Fluorophenyl-2-Nitro-Methylene-2H-1,4-Benzodiazepine-4-Oxide is a high-purity, specialized benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or a key precursor for the development of novel therapeutic agents targeting the central nervous system. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Development: Utilized in the early-stage development of potential anxiolytic, sedative, or other neuropsychiatric therapeutics.
• Academic Research: Employed in university and institutional labs for studying benzodiazepine receptor interactions and pharmacology.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial compounds for client-specific research needs.

Basic Information

Item	Details
Product Name	7-Chloro-1,3Dihydro-5-Fluorophenyl-2-Nitro-Methylene-2H-1,4-Benzodiazepine-4-Oxide
CAS No.	60656-76-0
Molecular Formula	C₁₆H₁₁ClFN₃O₃
Molecular Weight	347.73 g/mol
Synonyms	7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2-nitroso-2H-1,4-benzodiazepine 4-oxide; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-2-nitroso-2H-1,4-benzodiazepine 4-oxide; 5-(2-Fluorophenyl)-7-chloro-1,3-dihydro-2-nitroso-2H-1,4-benzodiazepine 4-oxide; Ro 07-9953/001; 2-Nitroso-7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine 4-oxide; 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one 4-oxide? (Tautomeric form); 2-Nitrosodemoxepam? (Related derivative)
EINECS	Contact for details

Quality Control

Our 7-Chloro-1,3Dihydro-5-Fluorophenyl-2-Nitro-Methylene-2H-1,4-Benzodiazepine-4-Oxide is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. All materials are subjected to rigorous analytical testing including HPLC, NMR, and mass spectrometry for identity confirmation and purity assessment. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.