Description

6-Chloro-2-(Chloromethyl)-4-(2-Fluorophenyl)Quinazoline 3-Oxide is a specialized quinazoline derivative, a key advanced pharmaceutical intermediate (API) in modern synthetic chemistry. This compound is valued for its unique halogenated and oxidized quinazoline structure, which is critical for imparting specific biological activity in final drug molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and targeted disease areas.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the research and development of new-generation pesticides and herbicides, leveraging its heterocyclic core.
• Chemical Synthesis: Acts as a versatile precursor for further functionalization, enabling the creation of complex molecular libraries for high-throughput screening.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for medicinal chemistry programs and structure-activity relationship (SAR) studies.
• Material Science Exploration: Investigated for potential applications in the development of organic electronic materials and specialty dyes.

Basic Information

Product Name	6-Chloro-2-(Chloromethyl)-4-(2-Fluorophenyl)Quinazoline 3-Oxide
CAS No.	60656-74-8
Molecular Formula	C₁₅H₉Cl₂FN₂O
Molecular Weight	323.15 g/mol
Synonyms	6-Chloro-2-(chloromethyl)-4-(2-fluorophenyl)quinazoline 3-oxide; 4-(2-Fluorophenyl)-6-chloro-2-(chloromethyl)quinazoline 3-oxide; 2-(Chloromethyl)-6-chloro-4-(2-fluorophenyl)quinazoline 3-oxide; Quinazoline, 6-chloro-2-(chloromethyl)-4-(2-fluorophenyl)-, 3-oxide; CAS 60656-74-8
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-(Chloromethyl)-4-(2-Fluorophenyl)Quinazoline 3-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.