Description

Thyrotropin-Releasing Hormone, Pro-Hydrazide- is a chemically modified derivative of the hypothalamic neuropeptide Thyrotropin-Releasing Hormone (TRH). This pro-hydrazide derivative is a critical intermediate in advanced peptide synthesis and biochemical research, offering a reactive handle for conjugation and labeling. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic researchers focused on neuroendocrinology and peptide-based therapeutic development.

Application

• Peptide Synthesis Intermediate: Serves as a key building block for the solid-phase or solution-phase synthesis of TRH analogs and conjugates.
• Bioconjugation & Labeling: The reactive hydrazide group enables site-specific coupling to carrier proteins, fluorescent dyes, or other molecules for diagnostic assay development.
• Neuroendocrine Research: Used in studies investigating the structure-activity relationship (SAR) of TRH and its receptor interactions.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for peptide characterization (HPLC, MS).
• Drug Discovery: A precursor in the development of novel peptide therapeutics targeting thyroid and central nervous system disorders.

Basic Information

Product Name	Thyrotropin-Releasing Hormone, Pro-Hydrazide-
CAS No.	60548-59-6
Molecular Formula	C16H23N7O4
Molecular Weight	377.40 g/mol
Synonyms	TRH Pro-Hydrazide; L-Pyroglutamyl-L-histidyl-L-prolinamide, 1-(Aminocarbonylhydrazide); Pyroglutamyl-Histidyl-Proline Amide Pro-Hydrazide; Pro-Hydrazide-TRH; (S)-5-Oxo-1-((S)-1-((S)-2-(hydrazinecarbonyl)pyrrolidine-1-carbonyl)-3-(1H-imidazol-4-yl)propyl)pyrrolidine-2-carboxamide; Thyroliberin Pro-Hydrazide; TRH-NHNH2
EINECS	Contact for details

Quality Control

Our Thyrotropin-Releasing Hormone, Pro-Hydrazide- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry (MS) for identity confirmation. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical values
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.