Description

Neurotensin (8-13) is a potent bioactive hexapeptide fragment derived from the endogenous neuropeptide Neurotensin. This compound is a critical research tool for studying neurotensin receptor (NTS1 and NTS2) signaling pathways and their physiological roles. It is primarily utilized by pharmaceutical researchers, neuroscientists, and biochemical suppliers focused on neuroscience, oncology, and metabolic disorder research.

Application

• Neuroscience Research: A key ligand for investigating the role of neurotensin in the central nervous system, including studies on dopamine modulation, pain perception, and thermoregulation.
• Receptor Binding Assays: Used in competitive binding studies to characterize neurotensin receptor subtypes (NTS1, NTS2) and screen for novel receptor agonists or antagonists.
• Cell Signaling Studies: Employed to activate neurotensin-mediated intracellular signaling cascades, such as calcium mobilization and MAPK/ERK pathways, in vitro.
• Cancer Research: Investigated for its effects on the proliferation and migration of various cancer cell lines that express neurotensin receptors.
• Drug Discovery & Development: Serves as a reference standard and pharmacophore model for designing new peptide-based therapeutics targeting neurotensin receptors.
• Biochemical Reagent: Supplied as a high-purity biochemical for use in assay kits, buffer solutions, and other research applications requiring defined peptide activity.

Basic Information

Product Name	Neurotensin (8-13)
CAS No.	60482-95-3
Molecular Formula	C₄₀H₆₂N₁₂O₈
Molecular Weight	822.99 g/mol
Synonyms	Arg-Arg-Pro-Tyr-Ile-Leu; Arg-Arg-Pro-Tyr-Ile-Leu-OH; Neurotensin Fragment 8-13; NT (8-13); H-Arg-Arg-Pro-Tyr-Ile-Leu-OH; Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu (8-13); Neurotensin hexapeptide; NT-8-13
EINECS	Contact for details

Quality Control

Our Neurotensin (8-13) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.