Description

Acetyl-Prolyl-Alanyl-Prolyl-Tyrosylamide is a synthetic peptide sequence of significant interest in biochemical and pharmaceutical research. This compound serves as a crucial building block and model substrate for studying enzyme kinetics, particularly for proteases like prolyl oligopeptidase. It is primarily utilized by research institutions and pharmaceutical developers focused on neurobiology, metabolic disorders, and peptide-based therapeutic discovery.

Application

• Biochemical Research: Used as a specific chromogenic or fluorogenic substrate for the study and characterization of prolyl oligopeptidase (POP) and related serine proteases.
• Pharmaceutical Development: Acts as a key intermediate or reference standard in the discovery and development of peptide-based drugs targeting neurological conditions.
• Enzyme Assay Kits: Incorporated into commercial and in-house diagnostic kits for measuring POP activity, relevant for research into bipolar disorder, Alzheimer's disease, and other pathologies.
• Metabolic Pathway Studies: Employed in vitro to investigate peptide metabolism and the role of specific cleavage events in cellular signaling.
• Quality Control Standard: Serves as a high-purity reference material for calibrating analytical instruments and validating methods in QC laboratories.

Basic Information

Product Name	Acetyl-Prolyl-Alanyl-Prolyl-Tyrosylamide
CAS No.	60240-19-9
Molecular Formula	C30H41N7O8
Molecular Weight	627.70 g/mol
Synonyms	Acetyl-Pro-Ala-Pro-Tyr-NH2; Ac-PAPY-NH2; N-Acetyl-L-prolyl-L-alanyl-L-prolyl-L-tyrosinamide; POP Substrate; Prolyl Oligopeptidase Substrate; Suc-Gly-Pro-Leu-Gly-Pro-AMC (related chromogenic analog); 60240-19-9; Ac-Pro-Ala-Pro-Tyr-NH2
EINECS	Contact for details

Quality Control

Our Acetyl-Prolyl-Alanyl-Prolyl-Tyrosylamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.