Description

Etomidate-002 is a high-purity pharmaceutical intermediate, specifically a derivative of the short-acting intravenous anesthetic agent Etomidate. This compound is critical for research and development in the synthesis of novel anesthetic and sedative formulations. It serves as a key building block for pharmaceutical manufacturers and advanced research institutions focused on central nervous system (CNS) drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of Etomidate and its related analogs for anesthetic applications.
• Research & Development: Serves as a critical reference standard and starting material in medicinal chemistry programs targeting GABAA receptor modulators.
• Process Chemistry: Used in scale-up and optimization of manufacturing routes for sedative-hypnotic active pharmaceutical ingredients (APIs).
• Analytical Standard: Employed as a high-purity calibrant in quality control laboratories for HPLC, GC, or LC-MS method development and validation.
• Preclinical Studies: Utilized in pharmacological research to study the structure-activity relationships (SAR) of imidazole-based anesthetics.

Basic Information

Product Name	Etomidate-002
CAS No.	60197-34-4
Molecular Formula	C14H16N2O2
Molecular Weight	244.29 g/mol
Synonyms	R-(+)-Etomidate; (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester; (+)-Etomidate; Ethyl (R)-(+)-1-(1-phenylethyl)-1H-imidazole-5-carboxylate; R-Etomidate; Dexetomidate; BRN 636543; HY-B0333; CCG-267037; AGN-PC-0D5QBY
EINECS	Contact for details

Quality Control

Our Etomidate-002 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing chromatographic purity, chiral purity, and residual solvent levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.