Description

5-Pyrimidinecarbonyl Chloride, 1,4-Dihydro-2-Methyl-4-Oxo- (9Ci) is a high-purity, reactive heterocyclic building block essential for advanced organic synthesis. This compound matters because it serves as a critical acylating agent and key intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). Pharmaceutical, agrochemical, and advanced material research laboratories need this chemical for its precise reactivity in introducing the 5-pyrimidinecarbonyl moiety into target molecules, enabling the creation of novel compounds with specific biological or material properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other small-molecule drug candidates targeting various diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators that require a pyrimidine core structure.
• Chemical Research & Development: Serves as a versatile acyl chloride reagent for introducing the dihydropyrimidinone carbonyl group in complex organic molecules during route scouting and process chemistry.
• Material Science: Potential building block for creating specialized polymers, ligands for catalysis, or organic electronic materials where the pyrimidine ring system imparts specific electronic properties.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.

Basic Information

Product Name	5-Pyrimidinecarbonyl Chloride, 1,4-Dihydro-2-Methyl-4-Oxo- (9Ci)
CAS No.	60186-49-4
Molecular Formula	C6H5ClN2O2
Molecular Weight	172.57 g/mol
Synonyms	1,4-Dihydro-2-methyl-4-oxo-5-pyrimidinecarbonyl chloride; 2-Methyl-4-oxo-1,4-dihydropyrimidine-5-carbonyl chloride; 5-Carboxy-2-methyl-4(1H)-pyrimidinone chloride; 5-(Chlorocarbonyl)-2-methyl-4(1H)-pyrimidinone; 2-Methyl-4(1H)-pyrimidinone-5-carbonyl chloride; 4-Hydroxy-2-methyl-5-pyrimidinecarbonyl chloride; 1H-Pyrimidine-5-carbonyl chloride, 1,4-dihydro-2-methyl-4-oxo-
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.