Description

Hemoglobin Chapel Hill is a specific, well-characterized variant of hemoglobin, a critical oxygen-transporting metalloprotein found in red blood cells. This product is essential for advanced biochemical research and diagnostic development, offering a consistent and high-purity reference material. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical development, and clinical diagnostics sectors who require precise hemoglobin standards for studies in hematology, oxygen transport kinetics, and genetic blood disorders.

Application

• Biochemical Research Standard: Serves as a purified reference standard for studying hemoglobin structure, function, and ligand-binding properties.
• Diagnostic Kit Development: Used in the calibration and validation of clinical diagnostic assays for hemoglobinopathies and blood gas analysis.
• Pharmaceutical Research: Employed in preclinical studies investigating oxygen therapeutics, blood substitutes, and treatments for sickle cell disease.
• Hematology Studies: Acts as a key reagent in research focused on oxygen transport efficiency, erythrocyte biology, and metabolic pathways.
• Educational & Reference Material: Provided as a high-quality teaching aid in university and professional laboratory settings for protein chemistry courses.
• Quality Control in Biomanufacturing: Utilized as a process control standard in the production of related biopharmaceuticals and diagnostic reagents.

Basic Information

Product Name	Hemoglobin Chapel Hill
CAS No.	60164-36-5
Molecular Formula	C2952H4664N812O832S8Fe4
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Chapel Hill; Hemoglobin variant Chapel Hill; Deoxyhemoglobin Chapel Hill; Oxyhemoglobin Chapel Hill; Methemoglobin Chapel Hill; Human Hemoglobin Chapel Hill; α2β2 Chapel Hill; Hemoglobin, Chapel Hill variant
EINECS	Contact for details

Quality Control

Our Hemoglobin Chapel Hill is produced and handled under stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including purity assessment by HPLC, spectral analysis for confirmation of the heme environment, and electrophoresis for variant identity and homogeneity. A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. Aliquot contents to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (IR / UV-Vis)	Conforms to standard
Purity (HPLC)	≥ 95% (Hemoglobin Chapel Hill)
Assay (Spectrophotometric)	≥ 90% functional hemoglobin
Methemoglobin Content	< 5%
Molecular Weight (SDS-PAGE)	~16 kDa (monomer), ~64 kDa (tetramer)
Endotoxin	< 1.0 EU/mg
Solubility	Clear solution in buffer (e.g., PBS, Tris)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.