Description

4-Fluoroaniline, n-Boc Protected is a key protected aniline derivative, specifically the tert-butoxycarbonyl (Boc) derivative of 4-fluoroaniline. This compound is essential for synthetic organic chemists as the Boc group provides a robust yet selectively removable protecting group for the amine functionality, enabling complex multi-step synthesis. It is primarily used in the research and development of pharmaceuticals, agrochemicals, and advanced materials, where precise control over molecular architecture is critical.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing fluorinated aromatic amines.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the fluorine atom and protected amine enhance bioactivity and stability.
• Peptide Chemistry: Acts as a protected amino acid precursor or a modifying agent in the synthesis of complex peptides and peptidomimetics.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials that require fluorinated aniline components.
• Cross-Coupling Reactions: Functions as a substrate in Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions to form complex C-N bonds.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorescent tags, molecular probes, and enzyme inhibitors for biochemical research.

Basic Information

Item	Details
Product Name	4-Fluoroaniline, n-Boc Protected
CAS No.	60144-53-8
Molecular Formula	C11H14FNO2
Molecular Weight	211.23 g/mol
Synonyms	N-Boc-4-fluoroaniline; tert-Butyl (4-fluorophenyl)carbamate; 1-(tert-Butoxycarbonylamino)-4-fluorobenzene; 4-Fluoro-N-(tert-butoxycarbonyl)aniline; Boc-4-fluoroaniline; N-(tert-Butoxycarbonyl)-4-fluoroaniline; 4-Fluoroaniline Boc derivative; (4-Fluorophenyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-Fluoroaniline, n-Boc Protected is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.