Description

Leu-Enkephalin Amide is a synthetic pentapeptide amide analog of the endogenous opioid peptide Leu-Enkephalin. This compound is a valuable research-grade biochemical tool, specifically engineered to enhance metabolic stability compared to its parent peptide. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and opioid receptor pharmacology.

Application

• Neuroscience Research: As a stable analog for studying the structure-activity relationships (SAR) of enkephalins and their interaction with delta (δ) and mu (μ) opioid receptors.
• Pharmacological Studies: Used in in vitro and ex vivo assays to investigate opioid signaling pathways, receptor binding affinity, and enzymatic degradation mechanisms.
• Biochemical Tool Development: Serves as a reference standard or control compound in the development of diagnostic assays and screening platforms for novel analgesics.
• Peptide Chemistry: An intermediate or model compound in peptide synthesis research for studying amidation techniques and stability modifications.

Basic Information

Product Name	Leu-Enkephalin Amide
CAS No.	60117-24-0
Molecular Formula	C28H37N5O7
Molecular Weight	555.63 g/mol
Synonyms	H-Tyr-Gly-Gly-Phe-Leu-NH2; Leu-Enkephalinamide; [Leu5]-Enkephalin amide; L-Leucine Enkephalin Amide; YGGFL-NH2; Tyr-Gly-Gly-Phe-Leu-NH2; Opioid Peptide (Leu-Enkephalin) Amide
EINECS	Contact for details

Quality Control

Our Leu-Enkephalin Amide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.