Description

S-(((3-(2,2,5,5-Tetramethylpyrrolidine-1-Oxy)Amino)Carbonyl)Methyl)-L-Cysteinyl-L-Tyrosine Amide is a specialized synthetic peptide derivative incorporating a stable nitroxide radical (TEMPO) moiety, making it a valuable tool in advanced biochemical research. This compound is primarily significant for its role as a spin label or probe in electron paramagnetic resonance (EPR) spectroscopy and related biophysical techniques. It is essential for researchers and developers in structural biology, protein dynamics studies, and pharmaceutical discovery who require site-specific labeling to investigate molecular interactions and conformational changes.

Application

• Site-Directed Spin Labeling (SDSL) in EPR spectroscopy for studying protein structure, dynamics, and folding.
• Biophysical Research Probe for investigating peptide-protein and protein-lipid interactions in membrane systems.
• Structural Biology Tool to map conformational changes and distances within biomolecules.
• Pharmaceutical R&D for the development and characterization of novel peptide-based therapeutics and drug delivery systems.
• Oxidative Stress Studies as a model compound or probe due to its nitroxide radical center.
• Material Science research for developing functionalized surfaces or polymers with radical tags.

Basic Information

Product Name	S-(((3-(2,2,5,5-Tetramethylpyrrolidine-1-Oxy)Amino)Carbonyl)Methyl)-L-Cysteinyl-L-Tyrosine Amide
CAS No.	60112-10-9
Molecular Formula	C₂₃H₃₅N₅O₅S
Molecular Weight	501.62 g/mol
Synonyms	SL-Tyr-Cys-NH₂ TEMPO; TEMPO-labeled Cysteine-Tyrosine Amide; (S)-2-Amino-3-((((3-((2,2,5,5-tetramethylpyrrolidin-1-yl)oxy)amino)-3-oxopropyl)thio)methyl)-3-(4-hydroxyphenyl)propanamide; Nitroxide Spin-Labeled Peptide; Cys-Tyr-NH₂ TEMPO adduct; EPR Probe Peptide; TEMPO-Cys-Tyr-NH₂; MTSSL-Cys-Tyr Amide derivative
EINECS	Contact for details

Quality Control

Our S-(((3-(2,2,5,5-Tetramethylpyrrolidine-1-Oxy)Amino)Carbonyl)Methyl)-L-Cysteinyl-L-Tyrosine Amide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and MS for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere to preserve the stability of the nitroxide radical. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
EPR Activity	Confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.