Description

Boc-D-Leu-Osu CAS NO 60111-76-4 is a high-purity, protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is essential for introducing the D-leucine residue with its tert-butoxycarbonyl (Boc) protecting group intact, enabling precise control over peptide sequence and stereochemistry. It is a critical reagent for pharmaceutical R&D, particularly in the development of novel therapeutic peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled, stepwise assembly of custom peptide sequences in research and manufacturing.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Development: Used to create stable, bioavailable analogs of natural peptides for therapeutic applications.
• Bioconjugation & Labeling: Facilitates the site-specific modification of peptides and proteins with tags, dyes, or other functional groups.
• Academic & Industrial Research: A staple reagent in biochemistry and medicinal chemistry laboratories for exploring protein structure-function relationships.
• Process Development & Scale-up: Employed in the development of robust and scalable synthetic routes for peptide production.

Basic Information

Product Name	Boc-D-Leu-Osu
CAS No.	60111-76-4
Molecular Formula	C16H26N2O6
Molecular Weight	342.39 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-leucine N-hydroxysuccinimide ester; Boc-D-leucine N-succinimidyl ester; N-Boc-D-leucine N-hydroxysuccinimide ester; N-Boc-D-leucine N-succinimidyl ester; N-(tert-Butoxycarbonyl)-D-leucine N-succinimidyl ester; Boc-D-Leu-OSu; N-Boc-D-Leu-OSu; D-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester
EINECS	262-091-4

Quality Control

Our Boc-D-Leu-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Melting Point	Specific range provided on COA
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.