Description

(+)-Tubocurarine Chloride Pentahydrate CAS NO 6989-98-6 is a purified, crystalline alkaloid salt derived from natural sources, recognized as a classic non-depolarizing neuromuscular blocking agent. Its primary value lies in its high pharmacological specificity for nicotinic acetylcholine receptors, making it a critical reference standard and research tool. This product is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors focusing on neuromuscular physiology, anesthetic mechanisms, and analytical method development.

Application

• Pharmacological Research: Used as a definitive competitive antagonist in studies of neuromuscular junction function and nicotinic acetylcholine receptor (nAChR) pharmacology.
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for identity, assay, and impurity testing in pharmaceutical quality control (QC) and method validation.
• Biochemical Studies: Employed in vitro to investigate signal transduction, ion channel blockade, and the structure-activity relationships of curare alkaloids.
• Educational & Historical Reference: Used in academic settings to demonstrate the principles of competitive antagonism and the history of anesthesia.
• Toxicology & Safety Testing: Applied in research models to understand the effects and antidotes for neuromuscular blocking agents.

Basic Information

Product Name	(+)-Tubocurarine Chloride Pentahydrate
CAS No.	6989-98-6
Molecular Formula	C37H41ClN2O6 • 5H2O
Molecular Weight	771.23 g/mol (Pentahydrate)
Synonyms	d-Tubocurarine Chloride Pentahydrate; Tubocurarine Chloride; (+)-Tubocurarine Chloride; Curare; Delacurarine; Intocostrin; Tubarine; Amelizol; Paracurarine
EINECS	230-287-6

Quality Control

Our (+)-Tubocurarine Chloride Pentahydrate is manufactured and handled under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identity confirmation by IR and NMR, purity assay by HPLC, and control of specific impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications. We support compliance with relevant pharmacopeial guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Avoid prolonged exposure to air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	10.0% - 13.0% (Theoretical for pentahydrate: ~11.68%)
Specific Rotation	[α]20/D +190° to +210° (c=1 in H2O)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.