Description

2',3'-o-Isopropylidene-2-Thiouridine is a key protected nucleoside derivative, specifically a thiouridine analog with an isopropylidene group protecting the 2' and 3' hydroxyls of the ribose sugar. This compound is a critical synthetic intermediate in the development of modified oligonucleotides and nucleoside-based therapeutics, offering researchers a versatile building block for probing RNA structure and function. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and specialty chemical manufacturers focused on antiviral drug discovery, antisense technology, and nucleic acid chemistry.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a protected monomer for the solid-phase or solution-phase synthesis of thio-modified RNA strands to study structure-activity relationships.
• Biochemical Research: A valuable tool for investigating RNA-protein interactions, ribozyme mechanisms, and the effects of sulfur substitution on nucleic acid stability and hybridization.
• Probe Development: Employed in creating labeled nucleosides for diagnostic assays and imaging studies due to the unique properties of the thio-carbonyl group.
• Medicinal Chemistry: Facilitates structure-based drug design by allowing the introduction of sulfur into specific positions of nucleoside scaffolds to modulate pharmacokinetic properties.

Basic Information

Product Name	2',3'-o-Isopropylidene-2-Thiouridine
CAS No.	6984-55-0
Molecular Formula	C12H16N2O5S
Molecular Weight	300.33 g/mol
Synonyms	2-Thiouridine, 2',3'-O-(1-methylethylidene)-; 2',3'-O-Isopropylidene-2-thiouridine; 2-Thio-2',3'-O-isopropylideneuridine; 1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-4-sulfanylpyrimidin-2-one; 2',3'-O-(1-Methylethylidene)-2-thiouridine; 2-Thio-2',3'-O-isopropylidene-uridine; Protected 2-Thiouridine
EINECS	Contact for details

Quality Control

Our 2',3'-o-Isopropylidene-2-Thiouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.