Description

2-(Pentafluorophenoxy)Ethyl Bromide is a specialized organofluorine building block featuring a reactive bromoethyl group attached to a pentafluorophenoxy moiety. This compound matters for its unique reactivity profile, enabling the efficient introduction of the pentafluorophenoxy (PFP) ester group, a key activating and leaving group in synthetic chemistry. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for synthesizing active pharmaceutical ingredients (APIs), ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: A key reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly in creating prodrugs or compounds requiring activated ester chemistry.
• Peptide & Protein Modification: Used as an activating agent for carboxylic acids, facilitating efficient amide bond formation in peptide synthesis and bioconjugation strategies.
• Agrochemical Synthesis: Serves as a versatile building block for creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Polymer & Material Science: Employed in the synthesis of functionalized polymers, dendrimers, and surface-modifying agents to impart specific chemical properties.
• Ligand & Catalyst Development: Useful for preparing specialized phosphine or nitrogen-based ligands used in homogeneous catalysis.
• Cross-linking Agent: Can act as a bifunctional linker in the preparation of cross-linked biomaterials or polymeric networks.
• Derivatization Reagent for Analytics: Applied in analytical chemistry to derivative compounds for improved detection via GC-MS or LC-MS.
• Fluorinated Compound Library Synthesis: A critical starting material in medicinal chemistry for generating diverse libraries of fluorinated compounds for screening.

Basic Information

Item	Details
Product Name	2-(Pentafluorophenoxy)Ethyl Bromide
CAS No.	6669-01-8
Molecular Formula	C8H4BrF5O
Molecular Weight	291.02 g/mol
Synonyms	2-Bromoethyl Pentafluorophenyl Ether; 1-Bromo-2-(pentafluorophenoxy)ethane; Pentafluorophenyl 2-Bromoethyl Ether; Ethanol, 2-bromo-, 1-(pentafluorophenyl) ether; 2-(Perfluorophenoxy)ethyl Bromide; PFP-Br
EINECS	Contact for details

Quality Control

Our 2-(Pentafluorophenoxy)Ethyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.