Description

4,5-Dichloropyrimidine is a high-value halogenated heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a versatile precursor in constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleoside analogs, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, leveraging the pyrimidine core's bioactivity.
• Material Science Research: Serves as a monomer or precursor for creating functional polymers and organic electronic materials.
• Cross-Coupling Reactions: The chlorine atoms provide excellent sites for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for molecular diversification.
• Nucleic Acid Chemistry: Used in the research and development of modified nucleosides and nucleotides.
• Chemical Library Development: A valuable scaffold for generating diverse compound libraries in drug discovery programs.

Basic Information

Product Name	4,5-Dichloropyrimidine
CAS No.	6554-61-6
Molecular Formula	C4H2Cl2N2
Molecular Weight	148.98 g/mol
Synonyms	4,5-Dichloro-1,3-diazine; 4,5-Dichloro-pyrimidine; Pyrimidine, 4,5-dichloro-; 1,3-Diazine, 4,5-dichloro-; NSC 403697; 4,5-DCP; Dichloropyrimidine
EINECS	229-479-5

Quality Control

Our 4,5-Dichloropyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.