Description

L-Leucyl-L-Leucine Methyl Ester (Hydrochloride) is a high-purity, protected dipeptide derivative essential for advanced peptide synthesis and biochemical research. This compound serves as a critical building block, offering a protected N-terminus and C-terminal methyl ester for controlled coupling and deprotection sequences. It is primarily utilized by research institutions and pharmaceutical developers engaged in peptide drug discovery, proteomics, and the study of enzyme-substrate interactions. Its defined structure and purity are vital for ensuring reproducibility in complex synthetic pathways.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled elongation of peptide chains, particularly in Fmoc/t-Bu strategies.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate protease specificity and kinetics.
• Pharmaceutical Development: Serves as a building block for the synthesis of novel therapeutic peptides and peptidomimetics.
• Proteomics & Mass Spectrometry: Can be employed as a reference standard or a derivatization agent in analytical workflows.
• Organic Synthesis: Utilized as a chiral synthon for the preparation of more complex, non-peptide molecules.

Basic Information

Product Name	L-Leucyl-L-Leucine Methyl Ester (Hydrochloride)
CAS No.	6491-83-4
Molecular Formula	C14H28N2O3 • HCl
Molecular Weight	308.85 g/mol
Synonyms	H-Leu-Leu-OMe • HCl; Leu-Leu Methyl Ester Hydrochloride; Methyl L-leucyl-L-leucinate hydrochloride; L-Leucyl-L-leucine methyl ester monohydrochloride; N-(L-Leucyl)-L-leucine methyl ester hydrochloride; (S)-Methyl 2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoate hydrochloride; Leucine, N-L-leucyl-, methyl ester, hydrochloride; LL-OMe • HCl
EINECS	Contact for details

Quality Control

Our L-Leucyl-L-Leucine Methyl Ester (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.