Description

1-Methylhistamine is a biologically significant histamine metabolite and a key intermediate in the synthesis of advanced pharmaceutical compounds. This compound is crucial for researchers and manufacturers requiring high-purity building blocks for drug discovery and development processes. It is primarily utilized in the pharmaceutical, biotechnology, and life science research sectors for creating novel therapeutic agents and conducting metabolic studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of histamine receptor ligands and other bioactive molecules.
• Biochemical Research: Used as a reference standard and reagent in studies of histamine metabolism, methylation pathways, and neurotransmitter function.
• Drug Discovery: Employed in medicinal chemistry programs targeting H3 and H4 histamine receptors for potential treatments in neurology and immunology.
• Metabolite Standard: Essential for analytical method development and validation in pharmacokinetic and bioanalytical studies.
• Enzyme Substrate: Utilized in enzymatic assays for histamine N-methyltransferase (HNMT) activity and inhibition studies.

Basic Information

Item	Details
Product Name	1-Methylhistamine
CAS No.	6481-98-7
Molecular Formula	C6H11N3
Molecular Weight	125.17 g/mol
Synonyms	1-Methyl-4-(2-aminoethyl)imidazole; N(τ)-Methylhistamine; Nτ-Methylhistamine; Tele-Methylhistamine; 1-Methyl-1H-imidazole-4-ethanamine; 2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine; Histamine, 1-methyl-; 4-(2-Aminoethyl)-1-methylimidazole
EINECS	Contact for details

Quality Control

Our 1-Methylhistamine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.