Description

1-Methylhistamine Dihydrochloride is a high-purity, pharmaceutically relevant derivative of histamine, a key biogenic amine. This compound is essential for research and development in neuropharmacology and immunology, serving as a crucial reference standard and synthetic intermediate. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents for investigating histamine receptor function and metabolic pathways.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) and method validation in drug development and quality control.
• Biochemical Research: Acts as a key metabolite and ligand in studies of histamine N-methyltransferase (HNMT) activity and histamine receptor subtype interactions.
• Diagnostic Reagent Manufacturing: Serves as a critical raw material in the production of immunoassay kits and other diagnostic tools for measuring histamine and its metabolites.
• Neuroscience & Immunology Studies: Employed in vitro and in vivo research to elucidate the role of methylated histamine derivatives in allergic responses, inflammation, and neurotransmission.
• Chemical Synthesis: Used as a protected or modified building block for the synthesis of more complex molecules targeting histaminergic systems.

Basic Information

Product Name	1-Methylhistamine Dihydrochloride
CAS No.	6481-48-7
Molecular Formula	C6H11N3·2HCl
Molecular Weight	214.10 g/mol
Synonyms	1-Methyl-4-(2-aminoethyl)imidazole dihydrochloride; Nτ-Methylhistamine dihydrochloride; Tele-Methylhistamine dihydrochloride; (2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine) dihydrochloride; 1-Methylhistamine 2HCl; Nt-Methylhistamine dihydrochloride; 4-(2-Aminoethyl)-1-methyl-1H-imidazole dihydrochloride
EINECS	Contact for details

Quality Control

Our 1-Methylhistamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and impurity profiling to ensure it meets the stringent requirements for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.