Description

Dl-Histidine Monohydrochloride CAS NO 6459-59-2 is the hydrochloride salt of the racemic mixture of the essential amino acid histidine. This compound serves as a critical chiral building block and biochemical reagent in advanced research and industrial synthesis. It is primarily utilized by manufacturers and research institutions in the pharmaceutical, nutraceutical, and biotechnology sectors for applications ranging from peptide synthesis to cell culture media formulation.

Application

• Pharmaceutical Intermediates: As a key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) and complex peptides.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, metabolic pathway analysis, and protein structure-function research.
• Cell Culture & Fermentation: Incorporated into defined media formulations to support the growth of mammalian and microbial cells in bioproduction.
• Nutraceutical & Dietary Supplements: As a source of histidine in specialized amino acid blends and infusion solutions.
• Cosmetic & Personal Care: Potential use in skin-conditioning formulations and hair care products due to its amino acid properties.
• Food Science & Flavor Enhancement: Research into its role as a flavor precursor or modulator in processed foods.

Basic Information

Product Name	Dl-Histidine Monohydrochloride
CAS No.	6459-59-2
Molecular Formula	C6H10N3O2•HCl
Molecular Weight	191.62 g/mol
Synonyms	DL-Histidine HCl; (±)-Histidine hydrochloride; Histidine hydrochloride racemic; 2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride; H-His-OH•HCl; L-Histidine hydrochloride (impurity reference); Racemic Histidine HCl; Histidine HCl salt
EINECS	229-256-3

Quality Control

Our Dl-Histidine Monohydrochloride is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Specifications can be aligned with various pharmacopeial standards (e.g., USP, EP) or custom requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent caking and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.5%
Optical Rotation	±0.2° to 0.0° (c=1 in H2O)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Related Substances (HPLC)	Total impurities ≤1.0%
Chloride Content (Titration)	18.0% - 19.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.