Description

[(2R,5R)-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)-2,5-Dihydrofuran-2-Yl]Methox is a high-purity, chiral nucleoside derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block (synthon) for the synthesis of novel antiviral and anticancer agents, particularly those targeting nucleic acid metabolism. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs) and nucleotide analogs.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Antiviral Drug Development: Research and production of novel therapeutic agents targeting viral polymerases (e.g., for hepatitis, herpesviruses).
• Oncology Research: Building block for creating nucleotide analogs used in chemotherapy and targeted cancer therapies.
• Prodrug Synthesis: Used in the development of prodrugs to enhance the bioavailability and efficacy of nucleoside pharmaceuticals.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to DNA/RNA synthesis and repair.
• Fine Chemical Synthesis: Valuable intermediate for constructing complex, stereochemically defined molecules in custom synthesis projects.

Basic Information

Product Name	[(2R,5R)-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)-2,5-Dihydrofuran-2-Yl]Methox
CAS No.	6453-60-7
Molecular Formula	C10H12N2O4
Molecular Weight	224.21 g/mol
Synonyms	1-[(2R,5R)-5-Methoxy-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; (2R,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5H-furan-2-yl methanol derivative; Thymine furanoside derivative; 5-Methyl-1-[(2R,5R)-5-(methoxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; Nucleoside analog intermediate; Chiral dihydrofuran nucleoside.
EINECS	Contact for details

Quality Control

Our [(2R,5R)-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)-2,5-Dihydrofuran-2-Yl]Methox is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.