Description

L-Methionine-1-14C CAS NO 6398-11-4 is a carbon-14 radiolabeled isotopologue of the essential sulfur-containing amino acid L-Methionine. This compound is a critical tool for metabolic pathway tracing and pharmacokinetic studies, offering researchers unparalleled insight into biochemical processes. It is primarily utilized by pharmaceutical R&D teams, agrochemical scientists, and academic institutions engaged in advanced life science research, drug development, and nutritional studies.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to study the absorption, distribution, metabolism, and excretion (ADME) of methionine-containing compounds and related drugs.
• Biochemical Pathway Analysis: Essential for tracing methionine and one-carbon unit metabolism, including transmethylation and transsulfuration pathways in cellular and animal models.
• Protein Synthesis and Turnover Research: Employed to investigate the rate of protein synthesis, degradation, and the dynamics of specific protein pools in biological systems.
• Nutritional and Metabolic Disorder Research: Facilitates studies on methionine requirements, homocysteine metabolism, and disorders related to sulfur amino acid metabolism.
• Agrochemical Research: Applied in studies to understand the uptake, translocation, and metabolism of methionine-based or related agrochemicals in plants.
• Radiopharmaceutical Precursor: Serves as a starting material or intermediate in the synthesis of more complex radiolabeled compounds for diagnostic imaging.

Basic Information

Product Name	L-Methionine-1-14C
CAS No.	6398-11-4
Molecular Formula	C14CH11NO2S
Molecular Weight	~150.21 g/mol (based on 14C)
Synonyms	(2S)-2-Amino-4-([14C]methylsulfanyl)butanoic acid; L-2-Amino-4-([14C]methylthio)butyric acid; (S)-2-Amino-4-([14C]methylmercapto)butyric acid; [1-14C]-L-Methionine; L-Methionine (carboxyl-14C); Methionine-1-14C; L-Met-1-14C
EINECS	Contact for details

Quality Control

Our radiolabeled compounds are manufactured and tested under stringent quality control protocols. Each batch of L-Methionine-1-14C is characterized for chemical and radiochemical purity using advanced analytical techniques, including HPLC with radiometric detection. Certificates of Analysis (COA) are provided, detailing specific activity, purity, and solvent composition, ensuring compliance with the exacting standards required for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a dedicated freezer within a controlled environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (IR / NMR)	Conforms to structure
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied as solution)	Ethanol:Water or as specified
Radioactivity Concentration	As per customer requirement (e.g., 1 mCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.