Description

Ac-His-Nhme is a protected histidine derivative, a crucial building block in peptide synthesis and medicinal chemistry research. Its primary value lies in enabling the controlled introduction of the histidine residue, which is essential for catalytic activity and metal binding in bioactive peptides. This high-purity intermediate is indispensable for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic agents and diagnostic tools.

Application

• Peptide Synthesis: A key protected amino acid derivative for solid-phase and solution-phase synthesis of complex peptides and proteins.
• Pharmaceutical Intermediates: Serves as a critical building block in the research and development of new drug candidates, particularly those targeting enzyme active sites.
• Bioconjugation: Used in the preparation of peptide-based conjugates for drug delivery systems and diagnostic probes.
• Biochemical Research: Essential for studying enzyme mechanisms, protein-protein interactions, and metal ion coordination in model systems.
• Catalyst Development: Employed in the design and synthesis of peptide-based catalysts and artificial enzymes.

Basic Information

Product Name	Ac-His-Nhme
CAS No.	6367-11-9
Molecular Formula	C9H15N3O3
Molecular Weight	213.24 g/mol
Synonyms	N-Acetyl-L-histidine methyl ester; Acetyl-L-histidine methyl ester; L-Histidine, N-acetyl-, methyl ester; Ac-L-His-OMe; Nα-Acetyl-L-histidine methyl ester; Ac-His-OMe; N-Acetylhistidine methyl ester; Methyl N-acetyl-L-histidinate
EINECS	Contact for details

Quality Control

Our Ac-His-Nhme CAS NO 6367-11-9 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.