Description

D-Histidine Hydrochloride Monohydrate is a high-purity, enantiomerically pure amino acid derivative essential for advanced biochemical and pharmaceutical research. This compound serves as a critical chiral building block and a key reference standard in the development of peptide-based therapeutics and diagnostic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical producers requiring precise stereochemical control for applications in drug discovery, nutritional science, and biochemical analysis.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide drugs and enzyme inhibitors.
• Biochemical Research: Used as a standard and reagent in enzymatic studies, metabolic pathway analysis, and protein structure-function research.
• Cell Culture Media: Incorporated as a defined component in specialized cell culture formulations and microbiological media.
• Nutritional Science: Employed in research on amino acid metabolism, dietary supplements, and clinical nutrition studies.
• Diagnostic Reagents: Serves as a raw material in the production of diagnostic kits and assays for clinical testing.
• Cosmetic Ingredients: Used in the formulation of high-end skincare products for its potential role in peptide-based anti-aging compounds.

Basic Information

Product Name	D-Histidine Hydrochloride Monohydrate
CAS No.	6341-24-8
Molecular Formula	C6H9N3O2 • HCl • H2O
Molecular Weight	209.62 g/mol
Synonyms	D-Histidine HCl Monohydrate; (R)-2-Amino-3-(1H-imidazol-4-yl)propanoic Acid Hydrochloride Monohydrate; D-Histidine Monohydrochloride Monohydrate; (R)-Histidine Hydrochloride Monohydrate; H-D-His-OH • HCl • H2O; D-Histidine HCl • H2O; D-Histidine Hydrochloride Hydrate
EINECS	228-732-3

Quality Control

Our D-Histidine Hydrochloride Monohydrate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for research and pharmaceutical use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]20/D	+11.5° to +13.5° (c=1 in H2O)
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	7.0% - 9.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.