Description

Nα,Nα,1-Tris(2-Cyanoethyl)-L-Histidine is a specialized, chemically modified derivative of the amino acid L-Histidine, designed for advanced research and synthesis applications. This compound is valued for its unique functionalization, which introduces multiple cyanoethyl groups, making it a critical intermediate in the development of novel peptides, biochemical probes, and pharmaceutical candidates. It is primarily sought by researchers and process chemists in the pharmaceutical, biotechnology, and fine chemical sectors for its role in creating molecules with tailored properties for drug discovery and biochemical studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Used to create labeled peptides and proteins for diagnostic assays, imaging, and biochemical research.
• Peptide Chemistry Research: Serves as a modified amino acid residue in solid-phase and solution-phase peptide synthesis to study structure-activity relationships.
• Ligand & Receptor Studies: Employed in the design of novel ligands for targeting specific biological receptors or enzymes.
• Fine Chemical Synthesis: Acts as a precursor in the multi-step synthesis of specialized organic compounds for high-value applications.
• Academic & Industrial R&D: Utilized in research laboratories for exploring new synthetic methodologies and chemical biology.

Basic Information

Product Name	Nα,Nα,1-Tris(2-Cyanoethyl)-L-Histidine
CAS No.	6329-07-3
Molecular Formula	C₁₈H₂₂N₈O₂
Molecular Weight	382.42 g/mol
Synonyms	Nα,Nα-Bis(2-cyanoethyl)-Nπ-(2-cyanoethyl)-L-histidine; L-Histidine, Nα,Nα,1-tris(2-cyanoethyl)-; Tris(2-cyanoethyl)histidine; 1-[Bis(2-cyanoethyl)amino]-3-(1H-imidazol-4-yl)-2-[(2-cyanoethyl)amino]propan-2-ol (tautomeric form); Nα,Nα-Bis(cyanoethyl)-Nπ-cyanoethyl-L-histidine; Modified L-Histidine derivative; Cyanoethylated L-Histidine
EINECS	Contact for details

Quality Control

Our Nα,Nα,1-Tris(2-Cyanoethyl)-L-Histidine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Standard specifications include assessment by HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.