Description

2-Amino-4-Phosphonobutyric Acid is a potent and selective antagonist of metabotropic glutamate receptors (mGluRs), specifically targeting group I and II subtypes. This compound is a critical research-grade biochemical for investigating glutamatergic signaling pathways in the central nervous system. It is essential for neuroscientists and pharmaceutical researchers studying synaptic plasticity, neurological disorders, and potential therapeutic targets.

Application

• Neuroscience Research: A key pharmacological tool for studying the role of metabotropic glutamate receptors (mGluRs) in synaptic transmission, long-term potentiation (LTP), and long-term depression (LTD).
• Drug Discovery & Development: Used in high-throughput screening and target validation assays for neurological conditions such as anxiety, depression, chronic pain, and neurodegenerative diseases (e.g., Alzheimer's, Parkinson's).
• Cellular Signaling Studies: Employed to elucidate intracellular signaling cascades, including phosphoinositide hydrolysis and cAMP modulation, activated by group I/II mGluRs.
• Electrophysiology: Applied in patch-clamp and field potential recordings to characterize the electrophysiological effects of mGluR blockade on neuronal excitability and network activity.
• Behavioral Pharmacology: Used in animal models to investigate the behavioral correlates of mGluR function and the potential efficacy of receptor antagonists.
• Biochemical Reagent: Serves as a reference standard and active ingredient in the formulation of specialized cell culture media and assay buffers for receptor studies.

Basic Information

Product Name	2-Amino-4-Phosphonobutyric Acid
CAS No.	6323-99-5
Molecular Formula	C₄H₁₀NO₅P
Molecular Weight	183.10 g/mol
Synonyms	AP4; DL-AP4; DL-2-Amino-4-phosphonobutyric acid; (±)-2-Amino-4-phosphonobutanoic acid; (RS)-2-Amino-4-phosphonobutanoic acid; 2-Amino-4-phosphono-butanoic acid; (RS)-AP4; L-AP4 isomer; Glutamate metabotropic receptor antagonist AP4
EINECS	Contact for details

Quality Control

Our 2-Amino-4-Phosphonobutyric Acid is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.