Description

2-Chloro-5-Hydroxybenzotrifluoride is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a reactive hydroxyl group and a stable trifluoromethyl group, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the bioisosteric trifluoromethyl group to enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the chloro and hydroxy groups offer sites for further functionalization.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific characteristics such as chemical resistance, thermal stability, or altered surface properties.
• Dye & Pigment Intermediate: Utilized in the production of high-performance, light-fast dyes and pigments for industrial applications.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel fluorinated compounds.

Basic Information

Product Name	2-Chloro-5-Hydroxybenzotrifluoride
CAS No.	6294-93-5
Molecular Formula	C7H4ClF3O
Molecular Weight	196.56 g/mol
Synonyms	5-Hydroxy-2-chlorobenzotrifluoride; 2-Chloro-α,α,α-trifluoro-m-cresol; 2-Chloro-α,α,α-trifluoro-5-hydroxybenzene; 3-Chloro-6-(trifluoromethyl)phenol; 2-Chloro-5-(trifluoromethyl)phenol; 5-Chloro-2-hydroxybenzotrifluoride (incorrect numbering but common alias); m-Chloro-α,α,α-trifluoro-p-cresol
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Hydroxybenzotrifluoride is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.