Description

4,6-Dichloro-2-Ethyl-5-Nitropyrimidine is a versatile halogenated nitropyrimidine building block of significant importance in advanced organic synthesis. Its core value lies in its reactive chlorine and nitro groups, which allow for selective functionalization to create complex heterocyclic systems. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other biologically active pyrimidine derivatives.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and plant growth regulators that leverage the pyrimidine scaffold.
• Chemical Research & Development: Serves as a versatile scaffold for constructing complex heterocyclic libraries in medicinal chemistry and material science.
• Material Science Precursor: Potential building block for the synthesis of specialty polymers, ligands, or organic electronic materials.
• Cross-Coupling Reactions: The chlorine atoms make it a suitable substrate for palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination.
• Nucleophilic Aromatic Substitution: The electron-deficient ring facilitates displacement of the chloro groups with various nucleophiles.

Basic Information

Product Name	4,6-Dichloro-2-Ethyl-5-Nitropyrimidine
CAS No.	6237-95-2
Molecular Formula	C6H5Cl2N3O2
Molecular Weight	222.03 g/mol
Synonyms	2-Ethyl-4,6-dichloro-5-nitropyrimidine; 5-Nitro-2-ethyl-4,6-dichloropyrimidine; 4,6-Dichloro-2-ethyl-5-nitro-pyrimidine; 2-Ethyl-5-nitro-4,6-dichloropyrimidine; 4,6-Dichloro-2-ethyl-5-nitropyrimidine; Pyrimidine, 4,6-dichloro-2-ethyl-5-nitro-
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-2-Ethyl-5-Nitropyrimidine is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.