Description

3-(5-Fluoro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Propanoic Acid is a high-purity fluorinated pyrimidine derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in its role as a key intermediate for the development of novel antiviral and anticancer agents, where the fluorine atom enhances metabolic stability and binding affinity. This compound is essential for research and development chemists, process development scientists, and manufacturers in the global pharmaceutical and fine chemical industries seeking to innovate in nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated nucleoside analogs and related active pharmaceutical ingredients (APIs).
• Antiviral Drug Development: Used in research and production of potential antiviral medications targeting viral polymerases.
• Oncology Research: Serves as a building block for creating novel chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Employed in academic and industrial laboratories for studying enzyme mechanisms and structure-activity relationships (SAR).
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for complex fluorinated molecules.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for clients.

Basic Information

Product Name	3-(5-Fluoro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Propanoic Acid
CAS No.	6214-60-4
Molecular Formula	C7H7FN2O4
Molecular Weight	202.14 g/mol
Synonyms	5-Fluoro-1-(2-carboxyethyl)uracil; 1-(2-Carboxyethyl)-5-fluorouracil; 5-Fluoro-1-(2-carboxyethyl)-2,4(1H,3H)-pyrimidinedione; 3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)propanoic acid; 5-Fluoro-1-(β-carboxyethyl)uracil; 5-FU-C2-COOH; 5-Fluorouracil-1-propionic Acid
EINECS	Contact for details

Quality Control

Our 3-(5-Fluoro-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Propanoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for each shipment, ensuring full traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.