Description

1-[(2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-(4-Methylphenyl)Sulfonyloxy-Oxolan-2-Yl]Pyrimidine-2,4-Dione is a sophisticated nucleoside derivative, a key intermediate in the synthesis of modified oligonucleotides and antiviral agents. Its precise stereochemistry and functionalization make it a critical building block for research and development in advanced pharmaceuticals. This compound is essential for scientists and manufacturers in the fields of nucleoside chemistry, antiviral drug discovery, and oligonucleotide therapeutics.

Application

• Antiviral Drug Intermediate: A crucial precursor in the synthesis of novel nucleoside analog antiviral agents targeting a range of viral infections.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-support building block for creating therapeutic antisense oligonucleotides (ASOs) and siRNA.
• Medicinal Chemistry Research: Serves as a key scaffold for structure-activity relationship (SAR) studies in drug discovery programs focused on nucleoside-based targets.
• Biochemical Probe Development: Employed in the creation of labeled or modified nucleosides for studying enzyme mechanisms and cellular processes.
• Pharmaceutical Reference Standard: Used as a high-purity standard for quality control and analytical method development in API manufacturing.

Basic Information

Product Name	1-[(2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-(4-Methylphenyl)Sulfonyloxy-Oxolan-2-Yl]Pyrimidine-2,4-Dione
CAS No.	6206-10-6
Molecular Formula	C₁₇H₂₀N₂O₈S
Molecular Weight	412.42 g/mol
Synonyms	Thymidine 3'-(p-toluenesulfonate); 3'-O-(p-Tolylsulfonyl)thymidine; 3'-O-Tosylthymidine; 2'-Deoxythymidine 3'-(4-methylbenzenesulfonate); 1-[(2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-[(4-methylphenyl)sulfonyl]oxyoxolan-2-yl]pyrimidine-2,4-dione; Thymidine 3'-tosylate; 3'-Tosylthymidine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D and GMP starting material applications. Every batch is characterized and tested to ensure high chemical purity, correct stereochemistry, and consistent performance in synthesis. Comprehensive analytical data, including HPLC, NMR, and MS, is provided with each shipment. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and reactivity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 98.5%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.