Description

Dl-5,5,5,5,5,5-Hexafluoroleucine CAS NO 6198-60-0 is a fluorinated derivative of the essential amino acid leucine, characterized by the substitution of all six hydrogen atoms on the terminal methyl groups with fluorine atoms. This strategic fluorination significantly alters its physicochemical properties, making it a critical building block for advanced research and development in medicinal chemistry. It is primarily sought after by pharmaceutical researchers and agrochemical developers for creating novel compounds with enhanced metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated peptide-based drugs and protease inhibitors.
• Medicinal Chemistry Research: Used to study the effects of fluorination on protein structure, function, and drug-target interactions (SAR studies).
• Positron Emission Tomography (PET) Tracer Development: Serves as a precursor for F-18 labeled compounds used in diagnostic imaging.
• Agrochemical Synthesis: Building block for novel fluorinated pesticides and herbicides with improved environmental persistence and efficacy.
• Biochemical Tool: Incorporation into peptides to modulate their stability against enzymatic degradation for biological assays.
• Material Science: Potential monomer or modifier for creating specialty polymers with unique surface properties.

Basic Information

Item	Detail
Product Name	Dl-5,5,5,5,5,5-Hexafluoroleucine
CAS No.	6198-60-0
Molecular Formula	C6H7F6NO2
Molecular Weight	239.12 g/mol
Synonyms	DL-5,5,5,5,5,5-Hexafluoroleucine; (RS)-5,5,5,5,5,5-Hexafluoroleucine; (±)-5,5,5,5,5,5-Hexafluoroleucine; 2-Amino-4,4,4-trifluoro-3-(trifluoromethyl)pentanoic acid; Hexafluoroleucine; 4,4,4-Trifluoro-3-(trifluoromethyl)-DL-norvaline
EINECS	Contact for details

Quality Control

Our Dl-5,5,5,5,5,5-Hexafluoroleucine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to verify the racemic mixture. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to ensure compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Racemic mixture (DL-form)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.