Description

Z-Gly-Gln-OH is a protected dipeptide derivative, widely recognized as a crucial building block in peptide synthesis. Its primary value lies in providing a controlled method for incorporating glutamine into peptide chains while protecting the reactive amine group with a benzyloxycarbonyl (Z) group. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of novel therapeutic peptides, peptide hormones, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of longer peptide sequences in both research and GMP manufacturing.
• Pharmaceutical Intermediate: Used in the research and production of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting metabolic, oncological, and neurological disorders.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies, substrate specificity investigations, and proteomics research.
• Peptide Library Construction: Employed in combinatorial chemistry for generating diverse peptide libraries used in drug discovery and high-throughput screening.
• Custom Peptide Synthesis: A fundamental component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.
• Conjugate Vaccine Development: Can be utilized in the synthesis of peptide antigens or haptens for conjugate vaccine research.

Basic Information

Product Name	Z-Gly-Gln-OH
CAS No.	6154-39-8
Molecular Formula	C₁₅H₂₀N₄O₆
Molecular Weight	352.35 g/mol
Synonyms	N-Benzyloxycarbonyl-glycyl-L-glutamine; Z-Gly-Gln; Z-Gly-L-Gln-OH; N-Cbz-Glycyl-L-glutamine; Cbz-Gly-Gln-OH; Benzyloxycarbonylglycyl-L-glutamine; Nα-Carbobenzoxy-glycyl-L-glutamine; (2S)-5-Amino-2-[[2-[(phenylmethoxy)carbonylamino]acetyl]amino]-5-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our Z-Gly-Gln-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in AcOH)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.