Description

D-Erythro-4-Hydroxyglutamic Acid is a non-proteinogenic amino acid derivative of glutamic acid, featuring an additional hydroxyl group on the carbon chain. This unique stereochemistry and functional group make it a valuable chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel compounds and studying biochemical pathways.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for neurological and metabolic targets.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, metabolic pathway analysis, and as a precursor for synthesizing more complex amino acids and peptides.
• Fine Chemical Synthesis: Acts as a building block for the production of specialty chemicals, complex organic molecules, and ligands for catalysis.
• Nutritional Science Studies: Employed in research related to amino acid metabolism, nutrient interactions, and the development of specialized nutritional formulations.

Basic Information

Product Name	D-Erythro-4-Hydroxyglutamic Acid
CAS No.	6148-21-6
Molecular Formula	C5H9NO5
Molecular Weight	163.13 g/mol
Synonyms	(2R,4R)-4-Hydroxyglutamic Acid; D-erythro-4-Hydroxy-L-glutamic Acid; (2R,4R)-2-Amino-4-hydroxypentanedioic Acid; 4-Hydroxy-D-glutamic Acid; HOG; 4-Hydroxyglutamate; D-4-Hydroxyglutamic Acid; (R,R)-4-Hydroxyglutamic Acid
EINECS	Contact for details

Quality Control

Our D-Erythro-4-Hydroxyglutamic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with key parameters including assay, chiral purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable and reproducible performance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (D-erythro)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.