Description

Benztropine Hbr is a high-purity pharmaceutical active ingredient, specifically a synthetic anticholinergic agent. It is critical for the formulation of medications used to manage neurological conditions, requiring stringent quality control for therapeutic efficacy and safety. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for Parkinson's disease and related movement disorders. Its reliable synthesis and consistent purity are paramount for downstream drug product quality.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of prescription medications for Parkinson's disease and drug-induced extrapyramidal symptoms.
• Neurological Research: Used as a reference standard and investigational compound in preclinical and clinical studies targeting cholinergic pathways.
• Generic Drug Formulation: A key component in the production of generic versions of anticholinergic therapies.
• Analytical Reference Standard: Serves as a high-purity standard in quality control laboratories for HPLC, GC, or spectroscopic assay methods.
• Chemical Intermediate: Potential use in the synthesis of more complex pharmaceutical molecules or derivatives for research purposes.

Basic Information

Product Name	Benztropine Hbr
CAS No.	6148-20-5
Molecular Formula	C₂₁H₂₅NO•HBr
Molecular Weight	404.34 g/mol
Synonyms	Benzatropine Hydrobromide; Benztropine Hydrobromide; 3α-(Diphenylmethoxy)tropane Hydrobromide; 3α-(Benzhydryloxy)tropane Hydrobromide; Cogentin (brand name); Tropine Benzohydryl Ether Hydrobromide; Endo-3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane Hydrobromide
EINECS	228-150-6

Quality Control

Our Benztropine Hbr is manufactured under strict quality management systems. It undergoes comprehensive analytical testing, including identification, assay, and impurity profiling, to ensure it meets pharmaceutical-grade standards. While not necessarily compendial (USP/EP), our quality protocols are designed to support drug development and manufacturing. A detailed Certificate of Analysis (COA) is provided with each batch to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.